C6
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FAQs
How do your chemical similarity scores work?
A score of 0.000 is given to identical conditions/screens, a score of 1.000 is given to the most dissimilar conditions/screens.
What is internal diversity?
Internal diversity is a measure of how similar each condition in a screen is to every other condition in the same screen – if the internal diversity is high (close to 1), then each condition in the screen is quite different from the other conditions (and indeed, the screen is either an additive screen or a sparse matrix screen). If the internal diversity is low (below 0.5) then then screen is probably a grid screen or a production screen.
What is a chemical factor?
A chemical factor is part of a crystallisation condition, and consists of a concentration, a unit, a chemical name [and maybe a pH]
How do you work out if a screen is PEGgy? (Or Salty?)
For each condition in the screen, we look at all the chemical factors and organise them by abundance (we translate all the units to w/v, then compare directly). Then we count the number of conditions that have a PEG as the primary factor. (we call the most abundant chemical the ‘primary factor’).
What do "buffer class" and "non-buffer class" mean?
Because different manufacturers and laboratories use different names to refer to the same chemicals, we have to use a generic term to effectively compare screens from different sources. Thus 'buffer class' is a generic term for a buffer. e.g. 'HEPES buffer class' would be used for either 'HEPES' or 'sodium HEPES'. (A 'non-buffer class' is a buffer whose pH is not within its usual pKa range or has no pH, that is, it is not acting as a buffer, and actually is exactly the same as just being a chemical)
How do I find out how similar two screens are?
Use the ‘Compare two screens’ report, and click through to find the screens you want.